Increased risk of hypokalemia (theoretical interaction). candesartan increases and methyclothiazide decreases serum potassium. Monitor Closely (1)hydrochlorothiazide, toremifene. Either increases toxicity of the other by pharmacodynamic synergism. candesartan increases and furosemide decreases serum potassium. hydrochlorothiazide increases toxicity of squill by Other (see comment). Use Caution/Monitor. The recommended starting dose of candesartan is 16 mg orally once a day when used as monotherapy in patients who are Effect of interaction is not clear, use caution. Mechanism: pharmacodynamic synergism. Opioids can reduce diuretic efficacy by inducing antidiuretic hormone release. Use Caution/Monitor.acebutolol, candesartan. For a child who cannot swallow an Atacand tablet whole, a pharmacist can mix the medicine into a liquid. Be sure to mention any of the following: angiotensin-converting enzyme (ACE) inhibitors such as benazepril (Lotensin, in Lotrel), captopril (Capoten, in Capozide), enalapril (Vasotec), fosinopril, lisinopril (in Prinzide, in Zestoretic), moexipril (Univasc, in Uniretic), perindopril, (Aceon), quinapril (Accupril, in Accuretic, in Quinaretic), ramipril (Altace), and trandolapril (Mavik, in Tarka); aspirin and other nonsteroidal anti-inflammatory medications (NSAIDs) such as ibuprofen (Advil, Motrin) and naproxen (Aleve, Naprosyn), diuretics ('water pills') including spironolactone (Aldactone, in Aldactazide); lithium (Lithobid); medications for diabetes; other medications for high blood pressure; and potassium supplements. Candesartan Cilexetil: BP Uses, Side Effects & Dosage - MedicineNet -Maintenance dose: 2 to 16 mg/day orally in 1 to 2 divided doses Monitor Closely (1)arformoterol and hydrochlorothiazide both decrease serum potassium. Therefore, you must continue to take it as directed if you expect to lower your blood pressure and keep it down. This list is not complete. Modify Therapy/Monitor Closely.amiloride increases and hydrochlorothiazide decreases serum potassium. Never take a double dose to make up for a forgotten one. WebCandesartan doses are based on weight in children and/or teenagers. Either increases toxicity of the other by pharmacodynamic synergism. Risk of fetal compromise if given during pregnancy. Use Caution/Monitor. NSAIDs decrease synthesis of vasodilating renal prostaglandins, and thus affect fluid homeostasis and may diminish antihypertensive effect. Effect of interaction is not clear, use caution. Thiazide dosage >50 mg/day may increase blood glucose. Comment: May result in renal function deterioration, particularly in elderly or volume depleted individuals. Mechanism: pharmacodynamic synergism. Use Caution/Monitor. Monitor Closely (1)hydrochlorothiazide will increase the level or effect of cefprozil by acidic (anionic) drug competition for renal tubular clearance. hydrochlorothiazide increases levels of calcium acetate by decreasing renal clearance. Use Caution/Monitor.celecoxib increases and hydrochlorothiazide decreases serum potassium. High blood pressure is a common condition, and when not treated it can cause damage to the brain, heart, blood vessels, kidneys, and other parts of the body. Modify Therapy/Monitor Closely.candesartan and drospirenone both increase serum potassium. Use Caution/Monitor. candesartan and choline magnesium trisalicylate both increase serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor. Use Caution/Monitor. Effect of interaction is not clear, use caution. empagliflozin, hydrochlorothiazide. Minor (2)candesartan and noni juice both increase serum potassium. hydrochlorothiazide decreases effects of insulin glargine by pharmacodynamic antagonism. Use Caution/Monitor. hydrochlorothiazide decreases effects of exenatide injectable solution by pharmacodynamic antagonism. Monitor Closely (3)candesartan and acebutolol both increase serum potassium. Use Caution/Monitor. candesartan and amiloride both increase serum potassium. carvedilol increases and hydrochlorothiazide decreases serum potassium. Monitor BP. Use Caution/Monitor. Effect of interaction is not clear, use caution. candesartan and diflunisal both increase serum potassium. Use Caution/Monitor. Avoid or Use Alternate Drug. Most Minor/Significance Unknown. Mechanism: pharmacodynamic synergism. Use Caution/Monitor. Effect of interaction is not clear, use caution. Comment: May result in renal function deterioration, particularly in elderly or volume depleted individuals. Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Effect of interaction is not clear, use caution. Use Caution/Monitor. cornsilk increases effects of candesartan by pharmacodynamic synergism. Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Atacand only for the indication prescribed. Use Caution/Monitor.Minor (1)hydrochlorothiazide will increase the level or effect of indomethacin by acidic (anionic) drug competition for renal tubular clearance. Use Caution/Monitor.Minor (1)levalbuterol, hydrochlorothiazide. Use Caution/Monitor. Minor/Significance Unknown. Use Caution/Monitor. Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Comment: Fentanyl can reduce the efficacy of diuretics by inducing antidiuretic hormone release. hydrochlorothiazide will increase the level or effect of ofloxacin by basic (cationic) drug competition for renal tubular clearance. Use Caution/Monitor. Either increases toxicity of the other by Other (see comment). Minor/Significance Unknown. Mechanism: pharmacodynamic synergism. Monitor for signs of diminished diuresis and/or effects on blood pressure and increase dosage of the diuretic as needed. Use Caution/Monitor. mefenamic acid decreases effects of candesartan by pharmacodynamic antagonism. Use Caution/Monitor. ketorolac decreases effects of candesartan by pharmacodynamic antagonism. Comment: Opioids can reduce the efficacy of diuretics by inducing the release of antidiuretic hormone. Monitor Closely (1)dobutamine and hydrochlorothiazide both decrease serum potassium. diclofenac increases and hydrochlorothiazide decreases serum potassium. Monitor Closely (4)ibuprofen decreases effects of candesartan by pharmacodynamic antagonism. Effect of interaction is not clear, use caution. Concomitant use of insulin and ARBs may require insulin dosage adjustment and increased glucose monitoring. Observe for possible additive hypotensive effects during concomitant use. Comment: Diuretics may cause hyperglycemia and glycosuria in patients with diabetes mellitus, possibly by diuretic-induced hpokalemia. Avoid or Use Alternate Drug. Thiazide dosage >50 mg/day may increase blood glucose. Effect of interaction is not clear, use caution. Minor/Significance Unknown. Effect of interaction is not clear, use caution. Avoid or Use Alternate Drug. cold symptoms such as stuffy or runny nose, sneezing, sore throat; This is not a complete list of side effects and others may occur. candesartan and diclofenac both increase serum potassium. Use Caution/Monitor. Mechanism: inhibition of mineralocorticoid steroid synthesis. Modify Therapy/Monitor Closely.candesartan and triamterene both increase serum potassium. Use Caution/Monitor. candesartan and meloxicam both increase serum potassium. Comment: May result in renal function deterioration, particularly in elderly or volume depleted individuals.candesartan and aspirin/citric acid/sodium bicarbonate both increase serum potassium. Risk of fetal compromise if given during pregnancy. Use Caution/Monitor. Minor/Significance Unknown. Manage and view all your plans together even plans in different states. Monitor Closely (1)telmisartan increases and hydrochlorothiazide decreases serum potassium. Minor/Significance Unknown. Use Caution/Monitor.candesartan and digoxin both increase serum potassium. Thiazide dosage >50 mg/day may increase blood glucose. hydrochlorothiazide decreases effects of pioglitazone by pharmacodynamic antagonism. Monitor Closely (1)eprosartan increases and hydrochlorothiazide decreases serum potassium. celiprolol increases and hydrochlorothiazide decreases serum potassium. When amifostine is used at chemotherapeutic doses, withhold blood pressure lowering medications for 24 hr prior to amifostine; if blood pressure lowering medication cannot be withheld, do not administer amifostine.amifostine, hydrochlorothiazide. If you log out, you will be required to enter your username and password the next time you visit. Minor/Significance Unknown. When amifostine is used at chemotherapeutic doses, withhold blood pressure lowering medications for 24 hr prior to amifostine; if blood pressure lowering medication cannot be withheld, do not administer amifostine. Modify Therapy/Monitor Closely. Use Caution/Monitor. Effect of interaction is not clear, use caution. Either increases toxicity of the other by Other (see comment). fenoprofen decreases effects of candesartan by pharmacodynamic antagonism. You may also have blood tests to check how well your kidneys are working and the amount of potassium in your blood. Minor/Significance Unknown. Monitor Closely (1)cyclosporine increases toxicity of hydrochlorothiazide by unspecified interaction mechanism. Use Caution/Monitor. hydrochlorothiazide and indapamide both decrease serum potassium. Use Caution/Monitor.meloxicam increases and hydrochlorothiazide decreases serum potassium. if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking candesartan. candesartan and fenbufen both increase serum potassium. Effect of interaction is not clear, use caution. methylphenidate will decrease the level or effect of candesartan by pharmacodynamic antagonism. Use Caution/Monitor. Minor/Significance Unknown. Minor/Significance Unknown. Minor/Significance Unknown. Do not let anyone else take your medication. Use Caution/Monitor. Comment: Thiazide diuretics may increase serum calcium by decreasing urinary calcium excretion. Modify Therapy/Monitor Closely. hydrochlorothiazide decreases levels of folic acid by increasing renal clearance. Mechanism: pharmacodynamic synergism. Effect of interaction is not clear, use caution. Use Caution/Monitor.Minor (1)formoterol, hydrochlorothiazide. Monitor Closely (4)candesartan, celecoxib. Minor/Significance Unknown. Other (see comment). We comply with the HONcode standard for trustworthy health information. Comment: May result in renal function deterioration, particularly in elderly or volume depleted individuals. Modify Therapy/Monitor Closely. Modify Therapy/Monitor Closely. Either increases toxicity of the other by Other (see comment). Use Caution/Monitor. NSAIDs decrease synthesis of vasodilating renal prostaglandins, and thus affect fluid homeostasis and may diminish antihypertensive effect. Mechanism: pharmacodynamic synergism. Use Caution/Monitor. Modify Therapy/Monitor Closely. Monitor Closely (1)methoxsalen, hydrochlorothiazide. 8 32 mg tablet total daily dose. Use Caution/Monitor. Risk of fetal compromise if given during pregnancy. candesartan and acebutolol both increase serum potassium. cosyntropin, hydrochlorothiazide. Effect of interaction is not clear, use caution. It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. Use Caution/Monitor. Effect of interaction is not clear, use caution. NSAIDs decrease synthesis of vasodilating renal prostaglandins, and thus affect fluid homeostasis and may diminish antihypertensive effect.Minor (1)hydrochlorothiazide will increase the level or effect of diclofenac by acidic (anionic) drug competition for renal tubular clearance. pirbuterol, hydrochlorothiazide. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely. candesartan, insulin degludec. Consider decreasing dosage of antihypertensive agent. Increased risk of systemic hyponatremia. Either increases toxicity of the other by Other (see comment). Most of the antihypertensive effect is attained within 4 weeks. Comment: Angiotensin II receptor antagonists may enhance hypoglycemic effects of antidiabetic agents by improving insulin sensitivity. Thiazide diuretics can decrease insulin sensitivity thereby leading to glucose intolerance and hyperglycemia. Either increases levels of the other by decreasing renal clearance. Atacand is an angiotensin II receptor blocker (sometimes called an ARB). Use Caution/Monitor. Open-label antihypertensive drug treatments were added as needed to achieve BP less than 140/90 mm Hg. candesartan and timolol both increase serum potassium. Thiazide dosage >50 mg/day may increase blood glucose. Serious - Use Alternative (1)candesartan, moexipril. Minor/Significance Unknown. Use Caution/Monitor. Minor/Significance Unknown. candesartan, meclofenamate. candesartan and sacubitril/valsartan both increase serum potassium. candesartan and penbutolol both increase serum potassium. choline magnesium trisalicylate decreases effects of candesartan by pharmacodynamic antagonism. candesartan and aspirin/citric acid/sodium bicarbonate both increase serum potassium. Take candesartan once each day, exactly as your doctor tells you to. Comment: Potential for increased risk of hypotension with concurrent use. Monitor Closely (1)vilanterol/fluticasone furoate inhaled and hydrochlorothiazide both decrease serum potassium. Either increases toxicity of the other by pharmacodynamic synergism. Effect of interaction is not clear, use caution. Coadministration of ARBs with sparsentan is associated with increased risks of hypotension, syncope, hyperkalemia, and changes in renal function (eg, acute renal failure). Use Caution/Monitor. Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. candesartan and nabumetone both increase serum potassium. amifostine, hydrochlorothiazide. Minor/Significance Unknown. Use Caution/Monitor. hydrochlorothiazide will increase the level or effect of aspirin/citric acid/sodium bicarbonate by acidic (anionic) drug competition for renal tubular clearance. Use Caution/Monitor. Candesartan: medicine to treat high blood pressure (hypertension This drug is available at a middle level co-pay. Use Caution/Monitor.ethacrynic acid and hydrochlorothiazide both decrease serum potassium. Use Caution/Monitor. Monitor Closely (3)pindolol increases and hydrochlorothiazide decreases serum potassium. Effect of interaction is not clear, use caution. ticarcillin, hydrochlorothiazide. hydrochlorothiazide decreases effects of chlorpropamide by pharmacodynamic antagonism. If your doctor prescribes a low-salt or low-sodium diet, follow these directions carefully. Either increases toxicity of the other by pharmacodynamic synergism. Hypokalemia. Use Caution/Monitor. Other (see comment). Mechanism: pharmacodynamic synergism. candesartan increases effects of insulin aspart protamine/insulin aspart by unspecified interaction mechanism. hydrochlorothiazide will increase the level or effect of fenbufen by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown. hydrochlorothiazide, carbenoxolone. Use Caution/Monitor. Minor/Significance Unknown. Effect of interaction is not clear, use caution. forskolin increases effects of hydrochlorothiazide by pharmacodynamic synergism. Use Caution/Monitor. Fentanyl may also lead to acute urinary retention by causing bladder sphincter spasm (particularly in men with enlarged prostates). Monitor Closely (1)penicillin G aqueous, hydrochlorothiazide. Monitor Closely (2)nitroglycerin rectal, candesartan. candesartan, aspirin/citric acid/sodium bicarbonate. Minor (1)hydrochlorothiazide increases levels of calcium chloride by decreasing renal clearance. Minor/Significance Unknown. Minor/Significance Unknown. Effect of interaction is not clear, use caution. Avoid administering other phototoxic drugs with aminolevulinic acid oral for 24 hr during perioperative period. informational and educational purposes only. Use Caution/Monitor. Use Caution/Monitor. Modify Therapy/Monitor Closely. Minor/Significance Unknown. Your doctor may adjust your dose as needed. Minor/Significance Unknown. Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. Risk of hypokalemia, especially with strong glucocorticoid activity. amifostine, candesartan. Either increases toxicity of the other by Other (see comment). Minor (1)cephalexin will increase the level or effect of hydrochlorothiazide by acidic (anionic) drug competition for renal tubular clearance. Use Caution/Monitor. The recommended dose range of candesartan for adults is 4 to 32 mg once daily. Effect of interaction is not clear, use caution. Comment: May result in renal function deterioration, particularly in elderly or volume depleted individuals. Minor/Significance Unknown. Comments: Mild to moderate renal dysfunction (CrCl 30 to 90 mL/min): No adjustment recommended Candesartan can cause injury or death to the unborn baby if you take the medicine during your second or third trimester. Comment: May result in renal function deterioration, particularly in elderly or volume depleted individuals.ketorolac increases and hydrochlorothiazide decreases serum potassium. Use Caution/Monitor. Effect of interaction is not clear, use caution. Use Caution/Monitor. Either increases toxicity of the other by Other (see comment). Hypokalemia. Minor/Significance Unknown. Minor/Significance Unknown. Use Caution/Monitor.carvedilol, candesartan. Comment: Theoretically, shepherd's purse may interfere with BP control. Modify Therapy/Monitor Closely. Minor/Significance Unknown. Use Caution/Monitor. Thiazide dosage >50 mg/day may increase blood glucose. Minor/Significance Unknown. methylphenidate transdermal decreases effects of candesartan by anti-hypertensive channel blocking. Minor/Significance Unknown. fentanyl transdermal decreases effects of hydrochlorothiazide by Other (see comment). The recipient will receive more details and instructions to access this offer. Minor/Significance Unknown. Stop using Atacand and tell your doctor right away if you become pregnant. Monitor Closely (3)betaxolol, candesartan. Monitor Closely (2)levodopa increases effects of hydrochlorothiazide by pharmacodynamic synergism. Use Caution/Monitor. Hypokalemia. Either increases toxicity of the other by pharmacodynamic synergism. Either increases toxicity of the other by Other (see comment). fentanyl intranasal decreases effects of hydrochlorothiazide by Other (see comment). Monitor Closely (1)hydrochlorothiazide, citalopram. Use Caution/Monitor. Use Caution/Monitor.Minor (2)norepinephrine, hydrochlorothiazide. Mechanism: pharmacodynamic synergism. Adverse reactions with combination products and individual agents, Discontinue as soon as possible when pregnancy is detected; affects renin-angiotensin system causing oligohydramnios, which may result in fetal injury and/or death, Hypersensitivity to candesartan, hydrochlorothiazide, or sulfonamides, Pregnancy (2nd and 3rd trimesters): Significant risk of fetal/neonatal morbidity and mortality, Severe hepatic impairment and/or cholestasis, Do not coadminister with aliskiren in patients with diabetes mellitus, Hypersensitivity reactions to hydrochlorothiazide may occur in patients with or without history of allergy or bronchial asthma, but are more likely in patients with such a history, Acute transient myopia and acute angle-closure glaucoma has been reported, particularly with history of sulfonamide or penicillin allergy (hydrochlorothiazide is a sulfonamide), Photosensitivity may occur; instruct patients taking hydrochlorothiazide to protect skin from sun and undergo regular skin cancer screening, Monitor serum electrolytes periodically; drugs that inhibit the renin-angiotensin system can cause hyperkalemia; hydrochlorothiazide can cause hypokalemia and hyponatremia; hypomagnesema can result in hypokalemia which appears difficult to treat despite potassium repletion, Thiazides decrease urinary calcium excretion and may cause mild elevation of serum calcium; avoid therapy in patients with hypercalcemia, Dual blockade of the renin angiotensin system with ARBs, ACE inhibitors, or aliskiren associated with increased risk for renal function changes (including acute renal failure) compared to monotherapy, Caution in aortic mitral stenosis, hepatic impairment, hypercholesterolemia, hypercalcemia, parathyroid disease, pre-existing renal insufficiency, systemic lupus erythematosus, bilateral renal artery stenosis or anuria, Hydrochlorothiazide may alter glucose tolerance and raise serum levels of cholesterol and triglycerides, Thiazides may decrease urinary calcium excretion, Symptomatic hypotension most likely to occur in patients who have been volume and/or salt depleted as a result of prolonged diuretic therapy, dietary salt restriction, dialysis, diarrhea, or vomiting may require temporarily reducing dose or volume repletion; volume and/or salt depletion should be corrected before initiating therapy, In patients with heart failure, therapy may cause excessive hypotension, which may lead to oliguria, azotemia, and (rarely) with acute renal failure and death; in such patients therapy should be started under close medical supervision; monitor closely for first 2 weeks of treatment and whenever dose of candesartan or diuretic is increased, Consider withholding or discontinuing therapy in patients who develop a clinically significant decrease in renal function, Hydrochlorothiazide may raise serum uric acid level due to reduced clearance of uric acid and may cause or exacerbate hyperuricemia and precipitate gout in susceptible patients, Thiazide diuretics reported to cause exacerbation or activation of systemic lupus erythematosus, Pregnancy Category: C (1st trimester); D (2nd and 3rd trimesters), Lactation: enters breast milk/contraindicated.