Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Registered trademark of Intervet International B.V. Used under license. It is recommended that SAFE-GUARD PREMIX 20% be diluted before addition to the feed. For oral use in cattle. There are several dewormers on the market that are approved for sheep. WebTitle. Contains 2.27 grams fenbendazole per lb. GROWING TURKEYS DOSAGE; Feed a Type C medicated feed containing 14.5 g fenbendazole/ ton (16 ppm) as the sole ration for SIX (6) CONSECUTIVE DAYS. Fenbendazole - Livestock Subcommittee Hosted by Katrin Bennhold. PO 1x and repeat in 14 days Moxidectin .1% A decrease in a drugs effectiveness overtime as calculated by fecal egg count reduction tests may indicate the development of resistance to the dewormer administered. Feed the resulting Type C medicated feed for THREE (3) CONSECUTIVE DAYS at a rate of 0.8lbs. Feeding directions for 1,000 lb body weight: 1 lb in a one day treatment. Updated: 2023-05-30. See label directions or visit Safeguard-Dewormer.com and click on animal species icon for dose calculator. Do Golden Retrievers Shed Like Crazy? Parasite Drug Dosages (all) Available for Android and iOS devices. 13 day slaughter withdrawal; no milk withdrawal. When handling the product, avoid inhalation, oral exposure and direct contact with skin or eyes. For instance, Safeguards (Fenbendazole) drug withdrawal time for goats on the label is 6 days when used at 5mg/kg for a single dose treatment. Safe-Guard You can find a list here. WebDose: Ampicillin sodium: 5 mg/lb, IV, TID to QID for Listeriosis 2. BIGHORN SHEEP: DOSAGE; Feed at a rate to supply 10 mg fenbendazole/ kg body weight (BW)/day (4.54 mg/lb/day) for THREE (3) CONSECUTIVE DAYS. Intestinal worms: Adult and developing 4th stage larvae of Cooperia punctata, C.oncophora, C.pectinata, C. mcmasteri, Trichostrongylus colubriformis, Nematodirus helvetianus, Bunostomum phlebotomum and Oesophagostomum radiatum. Safeguard Goat Dewormer is a widely available and effective dewormer for goats. Safe-Guard Dewormer for Beef & Dairy Cattle and Goats Consulting with a veterinarian is highly recommended before administering any medication to sheep. A decrease of effectiveness overtime may indicate the development of resistance to the dewormer administered. 0 However, it should not be used in dogs or cats, unless directed by a veterinarian. Following the use of any dewormer, effectiveness of treatment should be monitored. 3. A bigger bolus of medication in one spot will take longer to be absorbed and therefore longer to metabolize. Safe-Guard This means that the drugs safety and efficacy on sheep have not been evaluated by the Food and Drug Administration (FDA). When compared to other popular brands of dewormer, its easy to see SAFEGUARD is the most effective option as proven by the most current data.1. Deworming Backyard Poultry - Penn State Extension 2. All rights reserved. BIG HORN SHEEP DEWORMING/FEEDING DIRECTIONS. Directions for Use: Cattle (Beef and Dairy): For the removal and control of lung-worms, barber-pole worms, brown stomach worms, small stomach worms, hookworms, intestinal worms, bankrupt worms and nodular worms. Feed the resulting Type C medicated feed as the sole ration for THREE (3) CONSECUTIVE DAYS at the rate of 1.0 lbs. WebSafe-Guard Dewormer Suspension for Beef & Dairy Cattle & Goats. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Spam protection has stopped this request. Feed the resulting Type C medicated feed for THREE (3) CONSECUTIVE DAYS at a rate of 0.9 lbs. We comply with the HONcode standard for trustworthy health information. Safe-Guard Dewormer 20% Type A Medicated Article Small strongyles: Cyathostomum spp., Cylicocyclus spp. Data sources include IBM Watson Micromedex (updated 5 June 2023), Cerner Multum (updated 25 June 2023), ASHP (updated 11 June 2023) and others. It is intended to be administered as a one time treatment SC at the base of the ear in cattle and IM at the base of the ear in swine. (166890lb) of animal weight at the 2.5 mL/50 kg dose. June 30, 2023, 6:00 a.m. SAFE-GUARD (fenbendazole) is ready. This rule is to prevent any harmful drug residues from entering the human food chain. FOR GROWING TURKEYS ONLY. One liter deworms 43,478 lb. All horses must be eating normally to ensure that each animal consumes an adequate amount of medicated feed. We comply with the HONcode standard for trustworthy health information. About the Product Controls Major Worms Remember that anything you inject into your animal becomes a drug. endstream endobj startxref Sheep FERAL SWINE: For the treatment and control of: Kidney worms (Stephanurus dentatus), Roundworms (Ascaris suum), and Nodular worms (Oesophagostomum dentatum) in feral swine. The decision sharply curtails a policy that has long been a pillar of American higher education. THIS SERVICE AND DATA ARE PROVIDED "AS IS". EXAMPLES: Cattle: WebContains 2.27 grams fenbendazole per lb. The dosage and efficacy of the drug on sheep can vary widely, and the risk of adverse effects cannot be ruled out. Prior withdrawal of feed or water is not necessary. There are several measures that can be implemented to help mitigate the risk of resistance, including: - Anthelmintics should be used in the framework of an integrated parasite control program. While Safeguard Goat Dewormer may be a readily available dewormer for goats, it should not be used on sheep due to potential risks and lack of efficacy. BIGHORN SHEEP: For the treatment and control of: Lungworms (Protostrongylus spp.) Big Horn Sheep: 10 mg active drug ingredient Fenbendazole per kg of body weight per day, times (x) 3 days of treatment. Copyright 1995-2023 Merck & Co., Inc., Rahway, NJ, USA and its affiliates. Sheep are prone to contracting various parasites such as gastrointestinal worms, liver flukes, and lungworms. Safe-Guard Suspension 10% Dosage And Administration. This is primarily because resistance to one compound or brand may cause resistance to other members of the same class. Treated cattle must not be slaughtered for use in food for at least 13 days after the latest treatment with this drug. of BW to provide 1.14 mg/lb BW/day. 200 mg of fenbendazole/ml for oral administration via drinking water Safe-Guard AquaSol must be administered orally to chickens via the drinking water at a daily dose of 1.0 mg/kg BW (0.454 mg/lb.) However, there is confusion among some farmers and livestock owners regarding its suitability for sheep. Observe withdrawal periods: After giving your sheep Safeguard Goat Dewormer, ensure you observe the necessary withdrawal periods before consuming their milk or meat. The recommended dose of 2.3 mg/lb (5 mg/kg) is achieved when 2.3 ml of the drug are given for each 100 lbs body weight. of cattle. IF ANIMALS COULD TALK, THEY'D SAY JEFFERS! Ohio 4-H Youth Development Small Ruminant (Sheep/Goat), Sheep Equipment and Housing Plans Blueprints Colorado State University Extension, Sheep Building Plans North Dakota State University, American Consortium for Small Ruminant Parasite Control, Forages Ohio State University Extension, OSU Talking Sheep, Sheep Education and Information, If you have trouble accessing this page and need to request an alternate format, contact u@osu.edu. FREEDOM OF INFORMATION SUMMARY - Food and Drug You should weigh your dog to make sure you are using the right dose; i.e. All formulations of SAFE-GUARD are over 91% effective at eliminating such resistant parasites each exceeding the 90% recommended threshold. Make sure you get an accurate weight before dosing and if that isnt possible, for 5 consecutive days. (Previously published with the Eastern Alliance for Production Katahdins (EAPK): May 25, 2021), (Image Source: Dr. Jean-Marie Luginbuhl, North Carolina State University Sheep Anthelmintic Withdrawal Times). and whipworms (Trichuris spp.) Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Be careful if you decide to give drugs that are labelled for IV use by another route, some of these drugs can cause severe inflammation at the injection site. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. per head. For oral use in growing pigs, sows, gilts and boars. Different species metabolize the same drug at different speeds so you cannot assume the same withdrawal time applies. - Carefully follow the instructions given in the section DOSAGE AND ADMINISTRATION. WebAdd SAFE-GUARD. WebSafe-Guard (fenbendazole) Paste 10% is administered orally at a rate of 2.3 mg/lb (5 mg/kg) for the control of large strongyles, small strongyles, and pinworms. Jeanna Smialek, a Federal Reserve correspondent for The New York Times. Making informed decisions when it comes to livestock health ensures that they remain healthy and productive while minimizing the risk of adverse effects from medications. $30.00. 2021 Merck Animal Health Inc. All rights reserved. A decrease in a drugs effectiveness over time as calculated by fecal egg count reduction tests may indicate the development of resistance to the dewormer administered. Administer orally to cattle and horses at the recommended rate of 2.5mL/50kg (2.5mL/110lb) body weight using a dosing syringe or drenching gun. Storage: Store between Introduction: Understanding Safeguard Goat Dewormer, Deworming Practices for Sheep: An Overview. This means periodically switching to different dewormer products to keep parasites under control effectively. If you are using a prescription drug, it should come with a label listing the withdrawal time for the species that it was prescribed for. If its okay, this is a picture of the poop with the "segments". When it comes to deworming cattle, choose SAFE-GUARD to help get the most from your herd. Valley Vet Underdosing may result in ineffective treatment, and encourage the development of parasite resistance. WebDOSAGE AND ADMINISTRATION; USAGE. For drugs that list a maximum volume (ml) of product that can be administered in one site, you will also have an extended withdrawal time if you exceed that. for the following, Persian gazelles (Gazella subgutturosa subgutturosa), Kenya impala (Aepyceros melampus rendilis), Roosevelts gazelle (Gazella granti roosevelti), Thomsons gazelles (Gazella thomsoni thomsoni), Angolan roan antelope (Hippotragus equinus cottoni), Armenian mouflon (Ovis orientalis gmelini). Excede (Ceftiofur Crystalline Free Acid 200 mg/mL) a product labeled for respiratory infection in cattle and swine. A withdrawal period has not been established for this product in pre-ruminating calves. Add pounds. Thats how you know SAFE-GUARD means power. For the treatment of parasitic infections due to the following internal parasites in cattle: Lung worms: Adult and developing 4th stage larvae of Dictyocaulus viviparus. safe-guard (fenbendazole DIRECTIONS. This helps you monitor your sheeps health, tracks any adverse reactions, and ensures proper use of the medication. hbbd``b`#; $8D+^!` of feed ingredients to manufacture Type C medicated feed containing 14.5 grams of fenbendazole per ton equivalent. On the 4 th day Copyright 2023 Animalytix LLC. of BW to provide 4.08 mg fenbendazole per lb of BW. You can see the recommended records to keep here. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. %%EOF Potential Risks of Using Safeguard Goat Dewormer on Sheep, Conclusion: Making Informed Decisions for Sheep Health. CATTLE - Beef and Dairy: For the treatment and control of: Lungworms: Adult Dictyocaulus viviparus; Stomach worms: Adult brown stomach worms (Ostertagia ostertagi), Adult and fourth stage larvae barberpole worms (Haemonchus contortus), fourth stage larvae barberpole worms (H. placei), and Adult and fourth stage larvae small stomach worms (Trichostrongylus axei); Intestinal worms (Adult and fourth stage larvae): hookworms (Bunostomum phlebotomum), thread-necked intestinal worms (Nematodirus helvetianus), small intestinal worms (Cooperia punctata & C. oncophora), bankrupt worms (Trichostrongylus colubriformis), and nodular worms (Oesophagostomum radiatum). Safe-Guard Multi-Species Dewormer is a broad-spectrum, pelleted dewormer for use in beef and dairy cattle, equine, swine, growing turkeys, zoo and wildlife animals to aid in the removal and control of internal parasites. INDICATIONS - FENBENDAZOLE TYPE B MEDICATED FEED. Broad-spectrum, pelleted dewormer for use in beef and dairy cattle, equine, swine, growing turkeys, goats, zoo and wildlife animals. Do not underdose. Eastern Alliance for Production Katahdins (EAPK): May 25, 2021, Pasture Risk Management Decisions for Dry Weather, Sheep Lameness: Conditions and Treatments, Alternative Forages for Sheep and Goats in Drought Years. Not for use in beef calves less than 2 months of age, dairy calves, and veal calves. Consult your veterinarian for assistance in the diagnosis, treatment and control of parasitism. No withdrawal period is required for swine when treated according to the label. Must be thoroughly mixed in feeds before use. Do not underdose. used in a different species, at a different dose, for a different duration, etc. The content of this site contains information pertaining to The Ohio State University. Isabel Richards, Veterinary Science South Africa and owner/operator of Gibraltar Farm Know Your Dewormers | Livestock News | lancasterfarming.com Easily set accurate dosage up to 30 mL using the adjustor. It is also important to read and follow the product instructions carefully, as overdosing can lead to adverse effects and even death in sheep. Its important that you rotate through Fecal examinations or other diagnostic tests and parasite management history should be used to determine if the product is appropriate for the herd, prior to the use of any dewormer. For example, the recommended dose for procaine penicillin G (one of the few drugs labeled for sheep) has a withdrawal time in cattle of 14 days, in sheep 9 days and in pigs only 7 days. This cube provides an easy and convenient way to de-worm your herd. You must log in or register to reply here. Subcutaneous (SQ) medications are administered under the skin into the fatty tissue. Ensure She is an established authority in the pet blogging community, and her blog, "Paws and Claws," has been featured in numerous publications. Can Safeguard Goat Dewormer be Used on Sheep? Subtract parasites. Dewormer for Beef & Dairy Cattle, Swine, Growing Turkeys, Rocky Mountain Big Horn Sheep, Wildlife and Zoo Ruminants and Feral Swine, SAFE-GUARD (fenbendazole) 0.5% Medicated Dewormer Pellets. SAFE-GUARD also quickly reduces egg shedding and pasture contamination. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. No milk withholding time is required when the drug is used according to the label. They may seem safe, but many are absorbed systemically. Safe-Guard 4. It may not display this or other websites correctly. Antibiotics; Hoof Care; Implants; Injectable Vitamins; Safe-Guard Cattle Safe-Guard Premix 20% for Animal Use (Canada) - Drugs.com SWINE - Growing Pigs, Gilts, Pregnant Sows and Boars: DOSAGE; Feed as the sole ration for a period of 3-12 CONSECUTIVE DAYS so as to provide a total intake of 4.08 mg fenbendazole per pound (lb) of body weight (BW). Remember: De-wormers have drug withdrawal times too, check your labels. THIS SERVICE AND DATA ARE PROVIDED "AS IS". Animalytix assumes no liability, and each user assumes full risk, responsibility, and liability, related to its use of the Animalytix service and data. While Safeguard Goat Dewormer is specifically formulated for goats, it can also be used on sheep with some precautions. Intestinal worms: Adult and developing larval stages of the roundworm Ascaris suum, the whipworm Trichuris suis and the adult stage of the nodular worm Oesophagostomum dentatum. Re-treatment may be needed after 6-8 weeks. MEASURING SCOOP INCLUDED (8 oz (0.23KG)), Copyright 2023 Animalytix LLC. 1 kg pail (2 x 500 g bags) and 5 kg pail. You can look up drug withdrawal times for some commonly used extra label applications in sheep on the FARAD webpage. FARAD does not have enough data on the use of injected clove oil as it is not a drug and research has not been done to see what effects it may have in animals. Prior withdraw of feed or water is not necessary. HORSES: The recommended dose is 5 mg fenbendazole per kg body weight (BW) (2.27mg per pound (lb) BW) in a ONE (1) DAY treatment for large strongyles, small strongyles and pinworms. 5. Read the label. As an OTC product, the labeling for Safe-Guard Suspension 10% directs end-users to consult their Mix 1 pound (lb) of Type B (0.5%) medicated feed containing 4,540 g/ton of fenbendazole with 313.00 lbs. For oral use in all sheep, including pregnant ewes and breeding rams, and lambs. 612 0 obj <>/Filter/FlateDecode/ID[<3986E1ED8FB6924197851FC1C71C3135>]/Index[603 20]/Info 602 0 R/Length 63/Prev 270077/Root 604 0 R/Size 623/Type/XRef/W[1 2 1]>>stream The working premix is then blended with the complete feed mixture. The benzimidazole class includes fenbendazole (SafeGuard), albendazole (Valbazen) and oxfendazole (Synanthic). Parasite resistance may develop to any dewormer, and has been reported for most classes of dewormers. Store in a dry place, in original container. Parasite resistance may develop to any dewormer. Consult your veterinarian for assistance in the diagnosis, treatment, and control of parasites. Store at room temperature below 25C. Red-cote and Blu-cote have warnings on their label Not for use on food producing animals. in Bighorn sheep. Sheep may be more susceptible to adverse effects of the drug compared to goats, as they have a different metabolism. Choose suspension, paste or the feed formulation your cattle are already used to eating so you know theyll get their dose. ; 10 liters deworms 434,780 lb. Safe-Guard Suspension 10% for Animal Use (Canada). The following 2 tables summarize the different dewormers, dosages and withdrawal times that are recommended for sheep. See why a dewormer from the benzimidazole class, like SAFE-GUARD, may be the answer. Most people dont treat for tapeworms unless its obvious that they are causing an issue. For the treatment of parasitic infections due to the following gastrointestinal parasites in growing turkeys: Roundworms: Adults and larvae of Ascaridia dissimilis. Select one or more newsletters to continue. For dairy cattle, the milk discard time is 60 hours. Give 2.3 mL orally for each 100 lb body weight. A dilution of one part of SAFE-GUARD PREMIX 20% and nine parts of grain carrier is the suggested working premix. Available for Android and iOS devices. Why is the withdrawal time different if used in a species not listed on the label? Using the same Deworming Sheep: A Complete Guide 5 kg of premix will deworm 111 000 kg (244 900 lb) of swine. Tammy is passionate about educating pet owners and sharing her expertise, which is why she joined Arew.org, 88 Hollow Pine Dr Debary Florida(FL) 32713, 2023 Arew - WordPress Theme by Kadence WP. SAFE-GUARD for Cattle Fenbendazole Suspension, Stomach worms (adults and fourth stage larvae), Intestinal worms (adults and fourth stage larvae). Updated: 2023-05-30. Parasite resistance may develop to any dewormer, and has been reported for most classes of dewormers. All rights reserved. Be careful using drugs prescribed for your cattle in sheep as some drugs like Baytril (enrofloxacin) is not allowed to be used in sheep at all. In general, drugs that are given by this route clear quickly and have shorter withdrawal times. Tammy Slater is a pet blogger with a Bachelor's degree in Animal Science and extensive experience as a veterinary technician. 2 days for dairy cows, and 36 days for goats and sheep. SWINE - Growing Pigs, Gilts, Pregnant Sows and Boars: For the treatment and control of: Lungworms: Adult Metastrongylus apri, Adult Metastrongylus pudendotectus; Gastrointestinal worms: Adult and larvae (L3, L4 stages, liver, lung, intestinal forms) large roundworms (Ascaris suum), Adult nodular worms (Oesophagostomum dentatum, O.quadrispinulatum), Adult small stomach worms (Hyostrongylus rubidus), Adult and larvae (L2, L3, L4 stages - intestinal mucosal forms) whipworms (Trichuris suis); and Kidney worms: Adult and larvae Stephanurus dentatus. Intervet Canada Corp, 16750, route Transcanadienne, Kirkland, QC H9H 4M7. In this video, watch the step-by-step process for conducting an accurate FECRT, learn why theyre so important and see exactly what your results mean. SAFE-GUARD Cattle Deworming Schedule & Dosage Underdosing and/or sub-therapeutic concentrations of anthelmintic products may encourage the development of parasite resistance. If the product you are using has a withdrawal time listed for sheep, make sure you give it exactly as directed, do not exceed the maximum dose allowed in one injection site and do not give it for a longer period than is listed on the label. Debunking the Mystery: Understanding Your Dogs Post-Vaccine Behavior. Anyone tried Safeguard Range Cubes dewormer Consult with your Feeding directions for 1,000 lb body weight: For strongyles and pin-worms - 1 lb in a one day treatment. Webcattle and goats at a dose of 2.3 mg/lb (5 mg/kg) body weight (BW). Check the label and instructions carefully: Before administering Safeguard Goat Dewormer to sheep, its crucial to read the label and instructions carefully. Feed the resulting Type C medicated feed as the sole ration for ONE (1) DAY at the rate of 0.5pounds per 100 pounds of BW to provide 2.27 mg fenbendazole per lb of BW. In this article, we will explore the use of Safeguard Goat Dewormer on sheep and examine the potential risks involved. DVMetrics assumes no liability, and each user assumes full risk, responsibility, and liability, related to its use of the DVMetrics service and data. For dairy cattle, the milk discard time is 60 hours. Because relatively few antiparasitic drugs are FDA-approved for small ruminants, veterinarians often use antiparasitic drugs approved for other species in sheep and Apple-cinnamon flavor added makes this effective sheep paste wormer highly palatable. While some farmers may choose to use Safeguard Goat Dewormer off-label on sheep, it is not recommended. WILDLIFE AND ZOO RUMINANTS BIGHORN SHEEP AND FERAL SWINE: Do not use 14 days before or during the hunting season. THE SOLUTIONS YOU NEED TO GET THE JOB DONE. Animals that are sold at auction need to be ready to slaughter as many enter the food chain within hours or days after being sold. Use other dewormers alternatively: While Safeguard Goat Dewormer is suitable for some sheep, its essential to use other dewormers alternatively to prevent parasite resistance. However, there is some confusion about whether this medication can also be used on sheep. Respective University constituents are responsible for reviewing and maintaining up to date information. CATTLE: Do not use in beef calves less than 2 months old, dairy calves and veal calves. For ascarids, the recommended dose is 10 mg fenbendazole per kg BW (4.54mg per lb BW) in a ONE (1) DAY treatment. (2.3mL/100 lb. Available in 125mL, 1L, 10L, and 1G. If you try SAFE-GUARD and dont receive a fecal test result of 90% or above, Merck Animal Health will provide an additional SAFE-GUARD treatment for free. For the control of large and small strongyles, pinworms, ascarids, and 4th stage larvae of "strongyle vulgaris". Using the same drug to treat meningeal worm in sheep at 25mg/kg for 5 consecutive days has a significantly longer drug withdrawal time of 90 days. Updated: 2023-05-30. Click to see what We comply with the HONcode standard for trustworthy health information. Use tab to navigate through the menu items. Use the treatment schedule and dosage calculator to create your customized cattle deworming plan. Safe-Guard (fenbendazole) Paste | Pharmaceuticals - EQUINE The 500 mL format contains 50 000 mg of fenbendazole which is sufficient to treat 10000kg (22000 lb) of animal weight at the 2.5 mL/50 kg dose. Panacur Suspension 10% is approved as a prescription drug for beef and dairy cattle at a dose of 2.3 mg/lb (5 mg/kg) BW and for beef cattle at a dose of 4.6 mg/lb (10 mg/kg) BW. Toll-free 888-498-4444; local 514-428-7014. Higher doses of drugs take longer to metabolize and if too high, can be toxic to the liver or kidneys, slowing down the metabolism even more. SAFE-GUARD Dewormer for Cattle | Merck Animal Health USA For dairy cattle, the milk discard time is 96 hours. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. No. JavaScript is disabled. FREE SHIPPING ON MOST ORDERS OVER $49 Details. Tapeworms often cause concern among sheep and goat producers because producers can see the obviously expelled worms. For the treatment of parasitic infections due to the following internal parasites in growing pigs, sows, gilts and boars: Lung worms: Adult stage of Metastrongylus apri and M.pudendotectus. Retreatment may be required in six weeks, depending upon conditions of continued exposure to parasites, condition of treated animals and ambient temperatures. Last updated on May 9th, 2023 at 02:40 pm. Toll-free 888-498-4444; local 514-428-7014. Deworming is an essential part of sheep management that should not be overlooked. Safeguard Dewormer Cube is a 20% all natural protein cube which is medicated with Safeguard (Fenbendazole) cattle de-wormer. ), Small strongyles (Cyathostomum spp., Cylicocyclus spp., Cylicostephanus spp. ZOO AND WILDLIFE ANIMALS DOSAGE; RUMINANTS (subfamilies antilopinae, hippotraginae and caprinae) - DOSAGE; Feed at a rate to supply 2.5 mg of fenbendazole / kg body weight (BW) /day (1.14 mg/pound (lb) BW/day) for THREE (3) CONSECUTIVE DAYS.
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